Design and characterization of cefuroxime axetil biphasic floating minitablets

Cefuroxime axetil-induced liver failure.

Cefuroxime is a second-generation cephalosporin antibiotic. It is effective against susceptible bacteria causing infections of the middle ear, tonsillitis, throat infections, laryngitis, bronchitis, and pneumonia. It is also used in treating urinary tract infections, skin infections, and gonorrhea. It is a generally well tolerated antibiotic. Common adverse effects of cefuroxime axetil are diar...

Cefuroxime axetil to treat gonorrhea.

Pharmacokinetics and bactericidal activity of cefuroxime axetil.

The pharmacokinetics of cefuroxime axetil were studied in 10 adult volunteers aged 24 to 31 years (mean age, 27), 22 infants and children aged 11 to 68 months (mean age, 33 months), and 11 children aged 7 years, 7 months to 12 years, 3 months (mean age, 11 years, 1 month). Mean peak plasma concentrations of cefuroxime occurred between 90 and 120 min in all study patients and were independent of...

CODEN : IJPNL 6 Formulation and evaluation of bilayered floating tablets of cefuroxime axetil

Study aims to design a Gastro retentive Drug Delivery System of Cefuroxime axetil (CA). CA is a broad spectrum beta lactam type of antibiotic. More specifically, it is a second-generation cephalosporin. CA has site specific absorption from upper gastro intestinal tract and in intestine it undergoes hydrolysis to cefuroxime having poor absorption. Unabsorbed drug causes high concentration of ant...

formulation design and optimization of direct compressed tablets of cefuroxime axetil using experimental design